A corticosteroid such as dexamethasone may help, temporarily, if there is an obstruction due to tumour. Cyclizine is given by mouth. As diamorphine has a respiratory depressant effect, care should be taken when giving the drug to the very young and the elderly and a lower starting dose than normal is recommended. Sign Up Log In Cancel. Methylnaltrexone bromide is licensed for the treatment of opioid-induced constipation.
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The dose is given either as an immediate-release preparation 4-hourly or as a modified- release preparation hourly, in addition to rescue doses. Lower starting doses are recommended for patients with hepatic or renal impairment.
The ampoules are packed into a carton of 5. Continuous subcutaneous infusions Although drugs can usually be administered by mouth to control the symptoms of advanced cancer, the parenteral route may sometimes be necessary.
Prescribing in palliative care | Medicines guidance | BNF content published by NICE
Forms available from special-order manufacturers include: For the dose by subcutaneous infusion see below. Cyclizine is particularly likely to precipitate if mixed with diamorphine or other drugs see under Mixing and Compatibility, below Metoclopramide hydrochloride can cause skin reactions. Metoclopramide hydrochloride diwmorphine cause skin reactions. Midazolam Subcutaneous infusion solution should be monitored regularly both to check for precipitation and discolouration and to ensure that the infusion is running at the correct rate.
The dose should be suited to the individual patient. Levomepromazine is used as an antiemetic; it is given by mouth or by subcutaneous injection at bedtime.
Immediate-release morphine can be given for breakthrough pain. The product is prepared by dissolving Diamorphine Hydrochloride Lyophilisate for Solution for Injection in the requisite amount of water for injection immediately before use. By slow intravenous injection For Adult 1.
DIAMORPHINE HYDROCHLORIDE | Drug | BNF content published by NICE
Read more about the different types of painkillers. Gastro-intestinal pain The pain of bowel colic may be reduced by loperamide hydrochloride. There are no additional pre-clinical data of relevance to the prescriber.
By subcutaneous injection, or by intramuscular injection. Constipation is a common cause of distress and is almost invariable after administration of an opioid analgesic. Nerve blocks or regional anaesthesia syronge including the use of epidural and intrathecal catheters can be considered when pain is localised to a specific area.
Dry mouth may be caused by certain medications including opioids, antimuscarinic drugs e. Symptom control Several recommendations in this section involve unlicensed indications or routes. Show table of contents Hide table of contents 1.
There should be appropriate dosr of these problems before hypnotics are used.
It is predominantly a central nervous system depressant but it has stimulant actions resulting in nausea, vomiting and miosis. The number of drugs should be as few as possible, for even the taking of medicine may be an effort.
Some people worry about daimorphine addicted to diamorphine.
Haloperidol and levomepromazine can both be given as a subcutaneous infusion but sedation can limit the dose of levomepromazine. Morphine equivalences for transdermal opioid preparations have been approximated to allow comparison with available preparations of oral morphine. Report a side effect to the MHRA. Gastric distension pain due to pressure on the stomach may be helped by a preparation incorporating an antacid with an antiflatulent and a prokinetic such as domperidone before meals.
The following hour oral doses of morphine are considered to be approximately equivalent to the buprenorphine and fentanyl patches shown, however when switching due to possible opioid-induced hyperalgesia, reduce the calculated equivalent dose of the new opioid by one-quarter to one-half.
Intractable cough may be relieved by moist inhalations or by regular administration of oral morphine. A dose of 0. The following can be mixed with diamorphine: Enter medicine name or company Start typing to retrieve search suggestions. Each ampoule contains mg of Diamorphine Hydrochloride BP.